Best Anti-Aging Workouts, Seed Oils, Methylene Blue & Mitochondria | Dr. Chris Masterjohn, PhD

In this deep dive on mitochondrial health and longevity, Dr. Chris Masterjohn, PhD, challenges mainstream health narratives by arguing that fatigue and declining energy aren't caused by lack of sleep or poor diet alone—but by mitochondrial dysfunction. He explains how supplements like methylene blue can help in acute stress scenarios like high-altitude flights or breath-holding, but become harmful with chronic use, disrupting natural energy metabolism. Masterjohn emphasizes that one-size-fits-all health advice is dangerous, citing cases where patients worsened their health by taking methylene blue or creatine without proper testing. He advocates for personalized nutrition, highlighting the importance of choline, real fats like butter and red meat, and avoiding seed oils that damage mitochondria. The episode also covers the dangers of long-term SSRI use on mitochondrial function, the overlooked benefits of functional movement (like the Turkish getup) for preventing falls, and the risks of modern lifestyle factors such as EMFs and poor sun exposure. Masterjohn stresses that true health optimization requires self-awareness, testing, and a shift from passive consumption of wellness content to active, individualized practice.