Building a Biotech Investing Edge with Evan Markegard
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In this episode of Mission Matters Money, host Adam Torres welcomes Evan Markegaard, founder and managing partner at AUGC Partners LLC, to discuss his unique approach to biotech investing. Evan shares his journey from earning a PhD in oncology at UCSF to launching a science-driven biotech hedge fund after working at Genentech. He emphasizes his competitive edge—combining deep scientific expertise, a focus on small-cap biotech companies in early clinical stages, and value investing principles inspired by Warren Buffett and Seth Klarman. Evan highlights how his background allows him to identify undervalued, innovative companies before larger players, particularly in areas like cancer therapeutics and novel drug modalities. He also reflects on the value of high-intensity networking events like iConnections Miami and the JP Morgan Healthcare Conference, which enable direct access to founders and emerging data. The conversation underscores the power of niche expertise, long-term thinking, and the transformative potential of biotech innovation for patients and investors alike.
Leverage deep scientific expertise to identify undervalued biotech opportunities, especially in early-stage clinical trials.
Focus on small-cap biotech companies where liquidity is low and large funds can't easily invest, creating a competitive edge.
Apply value investing principles—margin of safety, long time horizons, and staying within your circle of competence—to biotech investing.
Attend high-intensity industry conferences like iConnections and JP Morgan Healthcare to build relationships and access early-stage data.
Look for companies with differentiated science, validated targets, and strong founder stories that align with real patient need.
…and 3 more takeaways available in PodZeus
Welcome & iConnections Miami Experience
Adam Torres introduces Evan Markegaard and sets the stage by discussing the iConnections Miami conference, where Evan attended for the first time. Evan shares his positive experience, highlighting the high volume of quality meetings and the unique networking environment.
AUGC Fund Origins & Scientific Edge
“I watched the fund after graduate school really based on a lot of fundamentals of digging into scientific investments. Very curious.”
From Science to Fund Formation
“I started investing actually when I was a teenager... reading Warren Buffett and Seth Klarman and focused on margin of safety and compounding and risk mitigation.”
The Biotech Investing Edge: Science, Small Caps & Value
“These smaller names too, Adam, they don't trade as much. There's not as much volume. So a lot of these big players... don't have the liquidity to invest in these smaller companies.”
Current Excitement & Future Outlook
Evan shares what excites him now: innovation in biotech, new scientific modalities, and the structural opportunity for pharma to acquire innovative small companies. He emphasizes the human impact and the beauty of the biotech ecosystem.
“I just love finding the innovative hidden gems before the pharma companies and before that validating data.”
“It's really a beautiful environment and structure. And I just love finding the innovative hidden gems before the pharma companies and before that validating data.”
“I started investing actually when I was a teenager... reading Warren Buffett and Seth Klarman and focused on margin of safety and compounding and risk mitigation.”
Host
Guest
Evan Markegaard
person
AUGC Partners LLC
organization
iConnections Miami
other
San Diego
place
UCSF
organization
Peter Kolshinsky
person
JP Morgan Healthcare Conference
other
RA Capital
organization
Genentech
organization
San Francisco
place
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