Fossilized squirrel poop full of ancient animals, and more…

Quirks and Quarks54mJune 12, 2026
AI-Generated Summary

Ancient fossilized squirrel poop from the Yukon is revealing a stunning snapshot of Ice Age ecosystems, with DNA from woolly mammoths, horses, and 200 plant species preserved in the digestive remains of ground squirrels. These 'middens'—frozen burrows filled with ancient droppings—act as unintentional time capsules, showing that some ecosystems shifted from open grasslands to shrublands in just 40 years, challenging the idea that environmental change is always gradual. Meanwhile, scientists have identified key genes—SP6 and SP8—that orchestrate limb regeneration in axolotls, mice, and zebrafish, offering a potential blueprint for future human regenerative medicine. In another breakthrough, a fungal protein found in Arctic lichens can trigger ice formation at surprisingly warm temperatures, suggesting microbes may play a crucial role in rain and snow formation. This 'bioprecipitation' could lead to eco-friendly cloud seeding. Finally, a new book reveals that our bodies are not static genetic blueprints but dynamic landscapes of mutation—where some changes cause disease, but others enable immunity, healing, and even longevity, turning our own cells into a living laboratory of evolution.

Key Takeaways
1

Ancient squirrel feces preserved in permafrost contain DNA from woolly mammoths, horses, and 200+ plant species, offering a detailed snapshot of Ice Age ecosystems.

2

Some ecosystems shifted from grassland to shrubland in as little as 40 years, indicating that environmental change can be rapid, not gradual.

3

The genes SP6 and SP8 act as molecular 'foremen' in limb regeneration across axolotls, mice, and zebrafish, guiding tissue repair at the site of injury.

4

Fungal proteins in Arctic lichens can nucleate ice at warm temperatures, suggesting microbes may play a key role in natural rain and snow formation.

5

Human cells accumulate mutations throughout life—not just from inheritance but from daily cell division and environmental stress, driving both disease and adaptation.

…and 3 more takeaways available in PodZeus

Chapters
0:00
3 min

Welcome to Quirks & Quarks

Introduction to the podcast and a brief mention of the Sounds Good newsletter for discovering new podcasts.

2:30
5 min

Ancient Squirrel Poop as Time Capsules

These unassuming bundles turned out to be ancient ground squirrel burrows, also called middens, dating anywhere from 30,000 to 700,000 years old.

Highlight
7:30
5 min

DNA from Fossilized Squirrel Poop

We were able to assemble 18 mitochondrial genomes from both the squirrels and the things that they ate such as the horses and bison. We were also able to assemble six mitochondrial genomes of woolly mammoths.

Highlight
12:30
5 min

Rapid Ecosystem Shifts in the Pleistocene

All the evidence from the pollen and the ancient DNA and other markers seems to suggest it went from mammoth step, open grass environment towards woody shrubland, totally different animals, in about 40 years.

Highlight
17:30
5 min

Axolotl Regeneration and the SP6/SP8 Genes

These genes in particular, again, they're transcription factors, so they're basically in... In the nucleus, they're sitting on DNA and they're basically deciding what genes need to be turned on or turned off.

Highlight
High-Impact Quotes
All the evidence from the pollen and the ancient DNA and other markers seems to suggest it went from mammoth step, open grass environment towards woody shrubland, totally different animals, in about 40 years.
Dr. Tyler Murchie8:46
So we were able to assemble 18 mitochondrial genomes from both the squirrels and the things that they ate such as the horses and bison. We were also able to assemble six mitochondrial genomes of woolly mammoths.
Dr. Tyler Murchie7:02
These genes in particular, again, they're transcription factors, so they're basically in... In the nucleus, they're sitting on DNA and they're basically deciding what genes need to be turned on or turned off.
Dr. Josh Curry15:41
Speakers

Host

Bob McDonald

Guests

Dr. Scott CockerDr. Tyler MurchieDr. Josh CurryRoxanne KamseyDr. Conrad Meister
Topics Discussed
fossilized squirrel poop95%mutations and health92%limb regeneration90%ancient dna preservation90%sp6 and sp8 genes88%microbial rainmaking85%ice age ecosystems85%rapid environmental change80%
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Roxanne Kamsey

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Dr. Josh Curry

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Dr. Conrad Meister

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Dr. Scott Cocker

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Hakai Institute

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McMaster University

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Max Planck Institute for Polymer Research

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