471 Biofilms, Biocides, and TTPC: A Deep Dive with Dr. Jeff Kramer

Scaling UP! H2O56mApril 10, 2026

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AI-Generated Summary

In this deep dive episode of Scaling UP! H2O, host Trace Blackmore sits down with Dr. Jeff Kramer, Technical Director at Radical Polymers, to explore the complex world of biofilms and biocides in industrial water treatment. The conversation begins with a personal reflection on their long-standing collaboration, including a memorable field trial with the biocide TTPC (tributyl tetradeca phosphonium chloride) that led to unexpected pump damage due to material incompatibility. Dr. Kramer explains that biofilms—communities of microorganisms embedded in a slimy matrix—are a pervasive issue in cooling systems, causing reduced heat transfer, increased corrosion, and acting as reservoirs for Legionella. He emphasizes that biofilms are up to an order of magnitude more insulating than mineral scales, making them a critical target for treatment. The episode dives into practical strategies for selecting and deploying biocides, stressing the importance of combining oxidizing biocides (like chlorine or bromine) with non-oxidizing biocides that both kill and remove biofilm. Dr. Kramer shares insights from lab testing methods, including coupon assays and sonication, to evaluate biocide performance. He highlights the significance of residence time, surfactant compatibility, and the risks of using biocides with co-solvents that can fuel microbial growth. The discussion also covers real-world challenges like interference between TTPC and PTSA, the need for supplier technical support, and the value of data-driven decision-making. The episode concludes with forward-looking insights on biocide blends and the importance of continuous innovation in water treatment.

Key Takeaways
1

Biofilms are 10x more insulating than mineral scales, significantly reducing heat transfer efficiency.

2

Effective biofilm control requires a combination of oxidizing and non-oxidizing biocides that both kill and remove biofilm.

3

Material compatibility is critical—TTPC can destroy PVC pumps; use high-density polyethylene, polypropylene, or PVDM instead.

4

Surfactants enhance biocide penetration by disrupting microbial membranes, improving kill speed and reducing required dosage.

5

Residence time determines biocide selection: short-turnover systems need fast-acting biocides (within 1–3 hours).

…and 3 more takeaways available in PodZeus

Chapters
0:00
10 min

Introduction and the Power of Real Water Training

Loren Rial introduces her practical, research-backed sales training for water treatment professionals, emphasizing real-world applicability and measurable results for growing revenue and strengthening customer relationships.

10:00
10 min

The Hidden Threat of Biofilms in Cooling Systems

Biofilms are actually an order of magnitude more insulating than mineral scales, so they're going to affect heat transfer.

Highlight
20:00
10 min

Dr. Jeff Kramer: A Veteran in Water Treatment Innovation

Dr. Jeff Kramer introduces himself, sharing his 30-year career at BWA Water Additives and his current role at Radical Polymers, highlighting his expertise in new product development and technical service.

30:00
10 min

The Science Behind Biofilm Testing and Biocide Evaluation

You can treat both coupons with the biocide and then sonicate one to count viable organisms and stain the other to look for remaining biofilm microscopically.

Highlight
40:00
10 min

Choosing the Right Biocide: Shock Dosing, Timing, and Compatibility

A high shock dose is going to be more effective than a low dose supplied even more frequently.

Highlight
High-Impact Quotes
When you're running a PTSA program and you slow dose in the TTPC, you see a quenching of the fluorescence... the system thinks that it doesn't have any inhibitor in it.
Dr. Jeff Kramer30:15
Viral: 90.0
Biofilms are actually an order of magnitude more insulating than mineral scales, so they're going to affect heat transfer.
Dr. Jeff Kramer12:49
Viral: 85.0
You have to understand the composition of your biocide... make sure that that's appropriate for the system that you're treating.
Dr. Jeff Kramer39:07
Viral: 80.0
Speakers

Host

Trace Blackmore

Guest

Dr. Jeff Kramer
Topics Discussed
biofilm formation and impact95%biocide selection and effectiveness90%material compatibility in water systems85%residence time and system dynamics80%surfactant chemistry in water treatment75%supplier support and technical partnership70%future innovations in biocide blends70%foam management in cooling systems65%
People & Brands

Dr. Jeff Kramer

person

15xPositive

Trace Blackmore

person

12xPositive

TTPC

product

10xPositive

PTSA

product

8xNeutral

Radical Polymers

organization

7xPositive

BWA Water Additives

organization

6xPositive

Center for Biofilm Engineering

organization

5xPositive

AMSAs

organization

5xPositive

Mike Standish

person

4xPositive

Loren Rial

person

4xPositive

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