Monsanto's Roundup at the Supreme Court

The Brian Lehrer Show19mApril 28, 2026

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AI-Generated Summary

The Brian Lehrer Show examines the Supreme Court's oral arguments in a landmark case involving Monsanto's Roundup herbicide, centered on John Durnell, a landscaper diagnosed with non-Hodgkin’s lymphoma after years of exposure. The case hinges not on whether glyphosate causes cancer—where the World Health Organization classifies it as a probable carcinogen and the EPA deems it not likely carcinogenic—but on whether state-level lawsuits can proceed despite federal pesticide regulation. The episode explores the deep scientific and political divide, highlighting how the EPA’s 2016 review failed to follow its own guidelines, prioritizing dietary exposure over occupational risk and pure glyphosate over formulated herbicides with potentially harmful inert ingredients. The Trump administration’s Justice Department argued on Monsanto’s behalf, contradicting RFK Jr.’s earlier stance and disappointing Maha movement activists who helped elect Trump. Experts Leanne Shepard and Maureen Grappi unpack the scientific evidence linking glyphosate to blood cancers, particularly non-Hodgkin’s lymphoma, and the public health implications of widespread exposure through diet and occupational use. Despite the lack of a clear signal from the justices during oral arguments, the episode underscores the broader stakes: if the Court rules in Monsanto’s favor, it could block tens of thousands of lawsuits and set a precedent limiting state-level accountability in public health matters.

Key Takeaways
1

The EPA’s 2016 glyphosate review failed to follow its own guidelines, focusing on low-dose dietary exposure rather than high-risk occupational exposure.

2

Glyphosate is detected in 70–80% of U.S. urine samples, suggesting widespread, chronic low-level exposure, particularly through non-organic foods like oats, wheat, and legumes.

3

The Supreme Court is not deciding if glyphosate causes cancer, but whether federal regulation preempts state lawsuits seeking warning label requirements.

4

RFK Jr.’s shift from calling glyphosate carcinogenic in January to supporting a Trump executive order boosting domestic production highlights the political entanglement of public health science.

5

Landscapers and pesticide applicators face the highest risk of non-Hodgkin’s lymphoma, with strong epidemiological evidence from the Agricultural Health Study linking high exposure to cancer.

…and 3 more takeaways available in PodZeus

Chapters
0:00
2 min

Introduction: Roundup, RFK Jr., and the Supreme Court

The episode opens with a recap of RFK Jr.'s congressional testimony and the Maha movement’s growing disillusionment with the Trump administration’s soft stance on glyphosate. The Supreme Court oral arguments in the John Durnell case are introduced as a pivotal moment in the ongoing battle over Roundup’s safety and liability.

2:00
3 min

The Scientific Divide: WHO vs. EPA

The EPA did not follow their own guidelines. There's also just been very strong industry influence that has impacted the way that EPA has done its work.

Highlight
5:00
5 min

John Durnell’s Case and the Legal Preemption Question

The question is, does the federal regulation of this preempt the kind of lawsuit that Mr. Dronell and tens of thousands of other people have brought or want to bring?

Highlight
10:00
5 min

Political Contradictions: RFK Jr. and the Maha Movement

The president has tried to push domestic, encourage domestic production of glyphosate. As you mentioned, the Justice Department was there arguing on behalf of the company in court.

Highlight
15:00
5 min

Public Health Implications and Future Activism

Professor Shepard discusses the biological plausibility of glyphosate causing non-Hodgkin’s lymphoma, including its potential to sequester in bone and its genotoxic effects. She offers practical public health advice, while Maureen Grappi reflects on the uncertainty of the Court’s decision and the broader implications for state autonomy and public health law.

High-Impact Quotes
It's not necessarily the case that they're doing something inconsistent with what EPA would do. It's simply a fact that they're responsive to the new information more quickly than the federal government is.
Chief Justice John Roberts16:23
Viral: 90.0
The EPA did not follow their own guidelines. There's also just been very strong industry influence that has impacted the way that EPA has done its work.
Leanne Shepard5:30
Viral: 85.0
The president has tried to push domestic, encourage domestic production of glyphosate. As you mentioned, the Justice Department was there arguing on behalf of the company in court.
Maureen Grappi8:26
Viral: 80.0
Speakers

Host

Brian Lehrer

Guests

Leanne ShepardMaureen Grappi
Topics Discussed
Glyphosate and Cancer Risk95%EPA Regulatory Failures90%Supreme Court Preemption Doctrine88%Industry Influence on Science85%Public Health and Occupational Exposure80%Political Contradictions in Public Health75%Organic Diet and Consumer Choices70%State vs. Federal Authority65%
People & Brands

Roundup

product

15xNegative

Monsanto

organization

12xNegative

Supreme Court

organization

12xNeutral

U.S. Environmental Protection Agency

organization

10xNegative

RFK Jr.

person

9xMixed

John Durnell

person

8xNeutral

Trump administration

organization

8xNegative

Maha movement

organization

6xNegative

Chief Justice John Roberts

person

5xNeutral

World Health Organization

organization

5xPositive

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