New Treatments for Recurrent Implantation Failure with guest Dr. Jenna Turocy
Recurrent implantation failure isn't a personal shortcoming—it's a medical condition, and the most promising new treatments are reshaping how we approach it. Dr. Jenna Turocy, a fertility specialist and biomedical engineer turned reproductive scientist, reveals that cutting-edge therapies like intrauterine platelet-rich plasma (PRP), peripheral blood mononuclear cell infusions, and subcutaneous granulocyte colony-stimulating factor (GCSF) are showing real promise in improving implantation rates—especially for patients with thin endometrial linings or a history of multiple failed transfers. But she also delivers a sobering warning: gene-editing tools like CRISPR, while scientifically fascinating, remain dangerously unready for clinical use, with one-third of embryos losing entire chromosomes during experimental editing. Her research underscores a critical truth: innovation must be tempered by caution. Patients, she insists, should advocate for themselves—not for experimental gene fixes, but for evidence-backed treatments like PRP and immune modulation, and to seek out specialists who stay current on the latest science. This episode is a call to action: stop blaming yourself, start demanding better care. The conversation shifts from lab bench to bedside with practical, patient-centered strategies. PRP, drawn from a patient’s own blood and injected into the uterus, acts like a regenerative 'growth cocktail' that thickens the uterine lining.
Recurrent implantation failure is a medical condition, not a personal failure—patients should stop blaming themselves.
Intrauterine platelet-rich plasma (PRP) can thicken a thin endometrial lining and improve implantation success in patients with recurrent implantation failure.
Subcutaneous GCSF injections show promise in improving pregnancy rates, but intrauterine GCSF does not—and may be ineffective.
CRISPR gene editing in embryos causes chromosomal loss in ~1/3 of cases, making it unsafe for clinical use today.
Patients should ask their fertility doctors about PRP, immune cell therapy, and GCSF if they’ve had multiple failed transfers.
…and 3 more takeaways available in PodZeus
Welcome & Introduction to Dr. Jenna Turocy
Dr. Amy introduces the episode and welcomes Dr. Jenna Turocy, a fertility specialist and biomedical engineer, highlighting her groundbreaking work in genomic medicine and recurrent implantation failure.
From Biomedical Engineering to Fertility Medicine
Dr. Turocy shares her journey from biomedical engineering to fertility care, emphasizing her passion for using technology to transform lives through reproductive science.
Genomic Medicine & the Ethics of CRISPR
“Approximately one third of the embryos lost an entire chromosome after being injected with CRISPR. That's not compatible with life.”
Reframing Recurrent Implantation Failure
“I hate the word failure. Don't you agree? ... It's a disease and fertility is a disease.”
PRP Therapy: Regenerating the Uterine Lining
“Think about like growth factors. So what the platelets are doing is they're stimulating growth factors so to help tissue grow and rejuvenate.”
“Approximately one third of the embryos lost an entire chromosome after being injected with CRISPR. That's not compatible with life.”
“So I tell patients, think about like growth factors. So what the platelets are doing is they're stimulating growth factors so to help tissue grow and rejuvenate.”
“So these studies have actually shown that GCSF in the uterus doesn't really help.”
Host
Guest
Dr. Jenna Turocy
person
Dr. Amy
person
platelet-rich plasma
other
granulocyte colony stimulating factor
other
CRISPR
other
peripheral blood mononuclear cells
other
Columbia University Fertility Center
organization
Fertility and Sterility
other
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