Does exercise lower your biological age?

Health Report39mJune 5, 2026
AI-Generated Summary

A groundbreaking new study suggests that regular physical activity may slow biological aging, but the evidence is far from conclusive. While researchers found a strong statistical association between higher step counts and a younger epigenetic age—measured by DNA methylation clocks like Horvath and GrimAge—this link comes from cross-sectional data that can't prove causation. The study, led by Professor Andrea Meyer from the National University of Singapore, highlights that physically active people tend to have better diets, sleep, and preventive health habits, which could be the real drivers behind their younger biological age. Still, the research points to physical activity as a powerful 'geroprotective' intervention, influencing cellular health through improved circulation, mitochondrial function, and the release of beneficial myokines. However, the episode also reveals a troubling paradox: despite the science, Australia is losing access to a critical hormone therapy (Zoladex) for breast cancer and endometriosis due to commercial decisions, raising alarms about drug pricing policies. Meanwhile, proposed changes to abortion access in multiple states threaten to criminalize care and restrict access for vulnerable women, particularly in rural areas.

Key Takeaways
1

Higher step counts are strongly linked to a younger epigenetic age, but this doesn't prove exercise causes biological aging reversal.

2

Physical activity may slow aging through cellular mechanisms like improved mitochondrial function and myokine release.

3

Cross-sectional studies cannot prove causation—healthier lifestyles may explain the link, not exercise alone.

4

Australia is removing the low-dose Zoladex implant from the PBS and private market, likely due to pricing disputes with AstraZeneca.

5

Proposed abortion restrictions in Queensland, NSW, and SA would severely limit access, especially for rural and Indigenous women.

…and 3 more takeaways available in PodZeus

Chapters
0:00
1 min

The Exercise Paradox: Can Movement Make You Biologically Younger?

The episode opens with Priya Alexander’s daily fitness routine, setting up the central question: does physical activity truly lower biological age? The discussion introduces epigenetic clocks as a measure of biological aging, laying the groundwork for the main scientific inquiry.

20:12
2 min

The Science of Biological Age and Physical Activity

Physical activity is the best geoprotective interventions anybody can do.

Highlight
22:13
3 min

Correlation vs. Causation: The Hidden Confounders

The episode explores the limitations of cross-sectional data, emphasizing that people who exercise regularly also tend to have healthier diets, better sleep, and more preventive care—factors that may be the real drivers of a younger biological age.

25:21
2 min

How Exercise Slows Aging at the Cellular Level

Professor Meyer explains the biological mechanisms behind exercise’s anti-aging effects, including improved circulation, mitochondrial health, and the release of myokines—hormones from muscle tissue that regulate brain and cellular function.

6:02
5 min

Zoladex Withdrawal: A Blow to Women’s Health

We're removing it off the PBS... because of commercial reasons.

Highlight
High-Impact Quotes
So physical activity is the best geoprotective interventions anybody can do.
Professor Andrea Meyer27:19
Taking away legal abortion rights will not reduce the number of abortions that happen. It will only reduce the safety of abortions.
Dr. Nisha Cott19:28
It just can't happen. It's not that we don't want to do this, it's that we can't do it.
Professor Paul Torzillo30:15
Speakers

Hosts

Priya AlexanderNorman Swan

Guests

Professor Andrea MeyerDr. Nisha CottProfessor Paul Torzillo
Topics Discussed
abortion access in australia95%Zoladex withdrawal92%biological age90%bulk billing changes90%physical activity and aging88%remote health services87%epigenetic clocks85%geroprotective interventions80%
People & Brands

AstraZeneca

organization

12xNegative

Medicare

organization

10xNeutral

Zoladex

product

10xNegative

Nisha Cott

person

8xPositive

Anumpa Health Council

organization

7xPositive

Paul Torzillo

person

6xPositive

Andrea Meyer

person

5xNeutral

Royal Australian and New Zealand College of Obstetrics and Gynaecology

organization

4xPositive

National University of Singapore

organization

3xNeutral

WHO

organization

3xNeutral

Start discovering podcast insights today

Start with a 7-day trial and explore a growing catalog of popular podcasts. No credit card required.

No credit card required • 7-day trial • Cancel anytime