Total Bases | MLB Picks Today: Tuesday Odds, Predictions & Best Bets | 4/21

In this episode of WagerTalk: Sports Betting Tips, the hosts dive into MLB picks for Tuesday, April 21, 2026, with a focus on key matchups including the Red Sox vs. Yankees, Mets vs. Twins, Guardians vs. Astros, Dodgers vs. Giants, and Cubs vs. Phillies. The team discusses pitching matchups, bullpen health, team trends, and statistical anomalies, with mixed confidence across games. While the Red Sox-Yankees game is seen as a coin flip due to inconsistent hitting and bullpen concerns, the hosts lean toward the Mets in their 11-game losing streak against Minnesota, citing poor pitching from Woods Richardson and the Twins' bullpen struggles. The Guardians vs. Astros game is viewed as a strong pitching advantage for Cleveland, but concerns over Parker Messick’s workload and Ryan Weiss’s lack of AAA experience lead to caution. The Dodgers-Giants game sees a split in opinion, with Brian favoring the Giants due to home-field advantage and team energy, while Tokyo Brandon and Adam lean toward the Dodgers. The Cubs are strongly favored over the Phillies due to a historically weak Phillies lineup against left-handed pitching and poor run differential. The episode concludes with a three-team parlay: Padres minus 140, Cubs minus 116, and Giants plus 1.5 at minus 115.