Daily Recap Day 1 + 2 EULAR 2026
A groundbreaking study presented at EULAR 2026 reveals that letting patients choose their rheumatoid arthritis (RA) biologic therapy—via a simple three-minute educational video—leads to significantly higher treatment satisfaction, better retention, and fewer adverse events, challenging the traditional top-down clinical model. This real-world validation of shared decision-making suggests that patient autonomy isn't just ethical but clinically impactful. Meanwhile, the meeting spotlighted the rising role of GLP-1 agonists in rheumatology, with emerging data on their anti-inflammatory effects beyond weight loss, though concerns about osteoporosis and muscle loss remain unaddressed. On the frontier of treatment, early data on CAR T-cell therapy in refractory RA showed dramatic remissions in six patients, but experts warn it’s too early for clinical use, especially given RA’s complex, T-cell-driven biology. Other key findings include a head-to-head trial showing equal efficacy between tocilizumab and abatacept post-TNF failure, and a promising new drug for IgG4-related disease that reduces flares and steroid use. Finally, a practical study on colchicine withdrawal in palindromic rheumatism offers real-world guidance: nearly 60% of patients remain in remission after stopping, but mega-dose misuse poses serious suicide risks, underscoring the need for careful prescribing.
Letting RA patients choose their biologic therapy via a 3-minute video leads to 50% higher retention and fewer adverse events compared to physician-only selection.
GLP-1 agonists may have direct anti-inflammatory effects in rheumatic diseases due to receptors in synovial fibroblasts, independent of weight loss.
CAR T-cell therapy achieved DAS remission in all six refractory RA patients, but long-term safety and applicability remain uncertain due to complex disease biology.
A head-to-head trial found tocilizumab and abatacept equally effective post-TNF failure, but tocilizumab showed better retention and monotherapy outcomes.
IgG4-related disease now has a new treatment option (obexelimab) that reduces flares by 60% and cuts steroid use by two-thirds, offering a non-depleting B-cell strategy.
…and 3 more takeaways available in PodZeus
Welcome to EULAR 2026: A Daily Recap from London
The podcast opens with a live broadcast from London, introducing the four faculty members and setting the stage for a deep dive into the most impactful abstracts from the first two days of EULAR 2026.
Patient Choice in RA Therapy: The Power of Shared Decision-Making
“When they choose, the story in their head is so much better and the buy-in and the retention and adverse, I thought that was so cool.”
GLP-1 Agonists: Beyond Weight Loss in Rheumatic Diseases
“Losing a dramatic amount of weight may cause that and we need to be mindful with our patients.”
Head-to-Head: Tocilizumab vs. Abatacept in TNF-Failure RA
“If you have a belief system that one is better than the other, then you could say tocilizumab had better retention and was better in monotherapy.”
CAR T-Cell Therapy in Refractory RA: Promising but Premature
“We need more studies. And then we'll make a decision if you were polyrefractory on pretty much everything, would you go for it with RA? Well, sure.”
“So that's, there was like 21 patients with FMF, young people up, mean age 28. And there was like, it's a, it's a mode of suicide. I didn't know that.”
“So hazard ratio 0 .44 if you're on active treatment, the rate of flares were approximately double on the people as they tapered prednisone on placebo versus active.”
“more and we need longer follow -up. And then we'll make a decision if you were polyrefractory on pretty much everything, would you go for it with RA? Well, sure.”
Host
Guests
rheumatoid arthritis
other
Orly Nair
person
Bella Metta
person
eular 2026
other
Janet Pope
person
Jack Kush
person
colchicine
product
tocilizumab
product
filgotinib
product
abatacept
product
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