Daily Recap Day 1 + 2 EULAR 2026

Rheumnow Podcast36mJune 4, 2026
AI-Generated Summary

A groundbreaking study presented at EULAR 2026 reveals that letting patients choose their rheumatoid arthritis (RA) biologic therapy—via a simple three-minute educational video—leads to significantly higher treatment satisfaction, better retention, and fewer adverse events, challenging the traditional top-down clinical model. This real-world validation of shared decision-making suggests that patient autonomy isn't just ethical but clinically impactful. Meanwhile, the meeting spotlighted the rising role of GLP-1 agonists in rheumatology, with emerging data on their anti-inflammatory effects beyond weight loss, though concerns about osteoporosis and muscle loss remain unaddressed. On the frontier of treatment, early data on CAR T-cell therapy in refractory RA showed dramatic remissions in six patients, but experts warn it’s too early for clinical use, especially given RA’s complex, T-cell-driven biology. Other key findings include a head-to-head trial showing equal efficacy between tocilizumab and abatacept post-TNF failure, and a promising new drug for IgG4-related disease that reduces flares and steroid use. Finally, a practical study on colchicine withdrawal in palindromic rheumatism offers real-world guidance: nearly 60% of patients remain in remission after stopping, but mega-dose misuse poses serious suicide risks, underscoring the need for careful prescribing.

Key Takeaways
1

Letting RA patients choose their biologic therapy via a 3-minute video leads to 50% higher retention and fewer adverse events compared to physician-only selection.

2

GLP-1 agonists may have direct anti-inflammatory effects in rheumatic diseases due to receptors in synovial fibroblasts, independent of weight loss.

3

CAR T-cell therapy achieved DAS remission in all six refractory RA patients, but long-term safety and applicability remain uncertain due to complex disease biology.

4

A head-to-head trial found tocilizumab and abatacept equally effective post-TNF failure, but tocilizumab showed better retention and monotherapy outcomes.

5

IgG4-related disease now has a new treatment option (obexelimab) that reduces flares by 60% and cuts steroid use by two-thirds, offering a non-depleting B-cell strategy.

…and 3 more takeaways available in PodZeus

Chapters
0:00
2 min

Welcome to EULAR 2026: A Daily Recap from London

The podcast opens with a live broadcast from London, introducing the four faculty members and setting the stage for a deep dive into the most impactful abstracts from the first two days of EULAR 2026.

2:18
3 min

Patient Choice in RA Therapy: The Power of Shared Decision-Making

When they choose, the story in their head is so much better and the buy-in and the retention and adverse, I thought that was so cool.

Highlight
7:26
3 min

GLP-1 Agonists: Beyond Weight Loss in Rheumatic Diseases

Losing a dramatic amount of weight may cause that and we need to be mindful with our patients.

Highlight
13:53
2 min

Head-to-Head: Tocilizumab vs. Abatacept in TNF-Failure RA

If you have a belief system that one is better than the other, then you could say tocilizumab had better retention and was better in monotherapy.

Highlight
18:09
3 min

CAR T-Cell Therapy in Refractory RA: Promising but Premature

We need more studies. And then we'll make a decision if you were polyrefractory on pretty much everything, would you go for it with RA? Well, sure.

Highlight
High-Impact Quotes
So that's, there was like 21 patients with FMF, young people up, mean age 28. And there was like, it's a, it's a mode of suicide. I didn't know that.
Orly Nair35:30
So hazard ratio 0 .44 if you're on active treatment, the rate of flares were approximately double on the people as they tapered prednisone on placebo versus active.
Janet Pope29:17
more and we need longer follow -up. And then we'll make a decision if you were polyrefractory on pretty much everything, would you go for it with RA? Well, sure.
Janet Pope24:07
Speakers

Host

Rheumnow Podcast

Guests

Jack KushBella MettaOrly NairJanet Pope
Topics Discussed
shared decision making in rheumatology90%glp-1 agonists and rheumatic diseases88%car t cell therapy in rheumatoid arthritis85%head to head trials in rheumatoid arthritis80%ig4-related disease treatment78%colchicine withdrawal in palindromic rheumatism75%gout treatment and de-escalation70%pregnancy in autoinflammatory diseases65%
People & Brands

rheumatoid arthritis

other

15xNeutral

Orly Nair

person

12xNeutral

Bella Metta

person

11xNeutral

eular 2026

other

10xPositive

Janet Pope

person

10xNeutral

Jack Kush

person

8xNeutral

colchicine

product

7xNeutral

tocilizumab

product

6xNeutral

filgotinib

product

5xNeutral

abatacept

product

5xNeutral

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