Day 3 Recap EULAR 2026

Rheumnow Podcast47mJune 5, 2026
AI-Generated Summary

The Rheumnow Podcast's Day 3 recap from EULAR 2026 in London delivers a sharp, candid critique of the conference's research output, with host Jack Kush bluntly calling the day 'pretty weak'—not for lack of educational content, but for a dearth of novel, high-impact science. Despite the criticism, the panel highlights several standout studies: a Mayo Clinic analysis using existing CT scans to reveal widespread muscle wasting (sarcopenia) in rheumatoid arthritis patients, which could reshape how we measure treatment success beyond joint scores; a small but intriguing Indian trial showing that starting axial spondyloarthritis treatment with infliximab before switching to tofacitinib leads to faster remission, a strategy justified by cost in low-resource settings; and real-world evidence from the ASTER study confirming anifrolumab’s effectiveness across multiple organ systems in lupus, especially skin, joints, and blood. The discussion also turns to the urgent, life-saving potential of emipalumab in macrophage activation syndrome associated with Still’s disease—where rapid response can mean survival—though the panel warns of underutilization and the need for better treatment sequencing. A final lightning round debunks a small RCT on probiotics in psoriatic arthritis, reinforcing that natural supplements shouldn’t replace evidence-based therapy, while also challenging the marketing-driven labeling of JAK inhibitors as 'mild' drugs.

Key Takeaways
1

Sarcopenia in RA patients is prevalent and measurable via existing CT scans, suggesting body composition should become a key outcome measure in trials.

2

Starting axial spondyloarthritis treatment with infliximab before switching to tofacitinib leads to faster remission, a strategy viable in low-resource settings.

3

Anifrolumab shows real-world effectiveness across multiple organ systems in lupus, especially skin, joints, and hematologic involvement.

4

Emipalumab provides rapid, life-saving response in Still’s disease-associated MAS, but remains underused due to cost and familiarity with older therapies.

5

JAK inhibitors like duclavacitinib are effective as monotherapy and should not be limited to mild disease based on marketing labels.

…and 3 more takeaways available in PodZeus

Chapters
0:00
2 min

Welcome to Day 3: Back to Real Posters

The hosts open the recap with a reflection on the return to physical posters at EULAR 2026, marking a shift from the digital format of the post-COVID era. The panel notes the tactile, immersive experience of real posters as a welcome change.

2:01
3 min

Sarcopenia in RA: A Hidden but Critical Outcome

I just thought it was really interesting overall, like I said, for introducing a component of RA that we may overlook but that patients prioritize utilizing existing imaging.

Highlight
7:27
3 min

Sequential Therapy in Axial SpA: Speed Over Cost

It allows them to gain some time. I know there are a lot of questions that may arise from this design. This is the first time I have seen it.

Highlight
15:01
3 min

Anifrolumab’s Real-World Impact in Lupus

It's reassuring data on the use of anifrolumab in SLE, particularly in patients who have organ involvement.

Highlight
21:09
4 min

Emipalumab: A Lifesaver in MAS, Underused

When these people turn, they turn quickly and they turn bad. And the numbers are going scary. It was scary yesterday. It's worse today.

Highlight
High-Impact Quotes
When these people turn, they turn quickly and they turn bad. And the numbers are going scary. It was scary yesterday. It's worse today.
Jack Kush25:38
I felt like the guy in the desert looking for water. So anyway, I just saw a few of you.
Jack Kush44:46
So I just thought it was really interesting overall, like I said, for introducing a component of RA that we may overlook but that patients prioritize utilizing existing imaging.
Jiha Lee5:03
Speakers

Host

Jack Kush

Guests

Sheila ReyesNelly ZiadehJiha Lee
Topics Discussed
emipalumab for macrophage activation syndrome92%sarcopenia in rheumatoid arthritis90%anifrolumab in systemic lupus erythematosus88%sequential therapy in axial spondyloarthritis85%TRM-SLE outcome measure82%EULAR 2026 research quality80%duclavacitinib monotherapy78%probiotics in psoriatic arthritis70%
People & Brands

emipalumab

product

15xPositive

anifrolumab

product

12xPositive

Jack Kush

person

10xNeutral

EULAR 2026

other

10xNeutral

macrophage activation syndrome

other

10xPositive

Sheila Reyes

person

8xNeutral

Still’s disease

other

8xNeutral

probiotics

product

7xNeutral

Nelly Ziadeh

person

7xNeutral

Jiha Lee

person

6xNeutral

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