Day 3 Recap EULAR 2026
The Rheumnow Podcast's Day 3 recap from EULAR 2026 in London delivers a sharp, candid critique of the conference's research output, with host Jack Kush bluntly calling the day 'pretty weak'—not for lack of educational content, but for a dearth of novel, high-impact science. Despite the criticism, the panel highlights several standout studies: a Mayo Clinic analysis using existing CT scans to reveal widespread muscle wasting (sarcopenia) in rheumatoid arthritis patients, which could reshape how we measure treatment success beyond joint scores; a small but intriguing Indian trial showing that starting axial spondyloarthritis treatment with infliximab before switching to tofacitinib leads to faster remission, a strategy justified by cost in low-resource settings; and real-world evidence from the ASTER study confirming anifrolumab’s effectiveness across multiple organ systems in lupus, especially skin, joints, and blood. The discussion also turns to the urgent, life-saving potential of emipalumab in macrophage activation syndrome associated with Still’s disease—where rapid response can mean survival—though the panel warns of underutilization and the need for better treatment sequencing. A final lightning round debunks a small RCT on probiotics in psoriatic arthritis, reinforcing that natural supplements shouldn’t replace evidence-based therapy, while also challenging the marketing-driven labeling of JAK inhibitors as 'mild' drugs.
Sarcopenia in RA patients is prevalent and measurable via existing CT scans, suggesting body composition should become a key outcome measure in trials.
Starting axial spondyloarthritis treatment with infliximab before switching to tofacitinib leads to faster remission, a strategy viable in low-resource settings.
Anifrolumab shows real-world effectiveness across multiple organ systems in lupus, especially skin, joints, and hematologic involvement.
Emipalumab provides rapid, life-saving response in Still’s disease-associated MAS, but remains underused due to cost and familiarity with older therapies.
JAK inhibitors like duclavacitinib are effective as monotherapy and should not be limited to mild disease based on marketing labels.
…and 3 more takeaways available in PodZeus
Welcome to Day 3: Back to Real Posters
The hosts open the recap with a reflection on the return to physical posters at EULAR 2026, marking a shift from the digital format of the post-COVID era. The panel notes the tactile, immersive experience of real posters as a welcome change.
Sarcopenia in RA: A Hidden but Critical Outcome
“I just thought it was really interesting overall, like I said, for introducing a component of RA that we may overlook but that patients prioritize utilizing existing imaging.”
Sequential Therapy in Axial SpA: Speed Over Cost
“It allows them to gain some time. I know there are a lot of questions that may arise from this design. This is the first time I have seen it.”
Anifrolumab’s Real-World Impact in Lupus
“It's reassuring data on the use of anifrolumab in SLE, particularly in patients who have organ involvement.”
Emipalumab: A Lifesaver in MAS, Underused
“When these people turn, they turn quickly and they turn bad. And the numbers are going scary. It was scary yesterday. It's worse today.”
“When these people turn, they turn quickly and they turn bad. And the numbers are going scary. It was scary yesterday. It's worse today.”
“I felt like the guy in the desert looking for water. So anyway, I just saw a few of you.”
“So I just thought it was really interesting overall, like I said, for introducing a component of RA that we may overlook but that patients prioritize utilizing existing imaging.”
Host
Guests
emipalumab
product
anifrolumab
product
Jack Kush
person
EULAR 2026
other
macrophage activation syndrome
other
Sheila Reyes
person
Still’s disease
other
probiotics
product
Nelly Ziadeh
person
Jiha Lee
person
Daily Recap Day 1 + 2 EULAR 2026
36m • 6/4/2026
EULAR 2026 Daily Podcast Day 1a
20m • 6/3/2026
EULAR 2026 Daily Podcast Day 2a
19m • 6/4/2026
EULAR 2026 Daily Podcast Day 2c
32m • 6/5/2026
EULAR 2026 Daily Podcast Day 3a
33m • 6/5/2026
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